General Information

  • ID:  hor003211
  • Uniprot ID:  NA
  • Protein name:  ACTH4-10
  • Gene name:  NA
  • Organism:  NA
  • Family:  Opioid neuropeptide precursor family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  MEHFRWG
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibition of inflammatory response
  • Mechanism:  Reduced KC release from macrophages
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  Macrophage activation:100 mM
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003211_AF2.pdbhor003211_ESM.pdb

Physical Information

Mass: 106929 Formula: C44H59N13O10S
Absent amino acids: ACDIKLNPQSTVY Common amino acids: EFGHMRW
pI: 7.55 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -111.43 Boman Index: -1779
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 0
Instability Index: 5000 Extinction Coefficient cystines: 5500
Absorbance 280nm: 916.67

Literature

  • PubMed ID:  10358199
  • Title:  POMC Gene-Derived Peptides Activate Melanocortin Type 3 Receptor on Murine Macrophages, Suppress Cytokine Release, and Inhibit Neutrophil Migration in Acute Experimental Inflammation